Last ned (Gratis)

Abstrakt

The hypothesis of a long-term glucose counterregulation is of particular interest in decision support in diabetes, but no long-term studies have been performed. Without an understanding of how hypoglycemia influences the glucose metabolism, diabetes patients are at higher risk of an unstable glucose control. The aim of this study was to evaluate the phenomenon using continuous glucose monitoring data with a data mining oriented approach. In a retrospective quasi-experimental data analysis we compared continuous glucose monitoring data from people with diabetes after spontaneous hypoglycemia with matched natural hypoglycemia-free control periods. Hypoglycemic events were free of preceding and subsequent hypoglycemia. Control periods were matched regarding subject and hypoglycemia-time and free of both near-hypoglycemia, preceding nearhypoglycemia and subsequent near-hypoglycemia. Insulin intake was also compared. 10 hypoglycemic events in 10 patients with type 1 diabetes were included. No significant difference in blood glucose was seen after hypoglycemia, but insulin intake was significantly higher for hours 6-24 after hypoglycemia. The little difference in blood glucose indicates no long-term glucose counterregulation to hypoglycemia. The hypoglycemic effect of increased insulin intake after hypoglycemia compared to in the control period together with resulting similar glucose levels could indicate hyperglycemic effects of hypoglycemia.

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